Endocrine Abstracts

Introduction: Although the cause and effect relationship between the hypophyseal deficiency and osteoporosis is known well, the number of studies concerning bone mineral density (BMD) in patients with Sheehan’s syndrome (SS) are scarce. We aimed to investigate the relationship between BMD and deficient hormones in patients with newly-diagnosed Sheehan’s syndrome.Material and methods: Thirty-four patients with SS and age-gender-weight matched 22...

We report a case of 28-year-old girl with panhypopituitarism and ectopic neurohypophysitis due to absent pituitary stalk. She was admitted to endocrinology policlinic with short stature, growth retardation and primary amenorrhea. Basal hormones indicated tahat she has secondary hypothyroidism, adrenal insufficiency, hypogonadism and GH insufficiency. Peak cortisol response to the short ACTH test was normal but inadequate to insulin tolerance test. The other dynamic pituitary f...

Lymphocytic hypophysitis (LH), an uncommon pituitary disorder that is considered an autoimmune disease. The disease shows a striking female predilection of ~9:1 and commonly affects young women during late pregnancy or in the postpartum period. Less frequently, it has also been observed in men and postmenaposal woman. Partial or total hypopituitarism can be in LH. In the early stage, the pituitary gland is enlarged like a pituitary tumor, from which it cannot be distinguished ...

Patients with inappropriate TSH syndrome have elevated serum free thyroxine (FT4) and free triiodothyronine (FT3) concentrations and normal or slightly elevated serum thyroid stimulating hormone (TSH) level. Inappropriate TSH syndrome include generalized resistance to thyroid hormone (GRTH), pituitary resistance of thyroid hormone (PRTH) and TSHoma.We report here three cases that the first patient has GRTH, the second has TSHoma and third patient has PRT...

Impaired glucose tolerance (IGT) and metabolic syndrome (MS) is considered as the pre-diabetic stages. Recently, it has been suggested that inflammation is associated with the components of MS and it may also have a role in the development of type 2 Diabetes Mellitus (DM). The aim of this study was to investigate the effects of inflammation in the pathogenesis of DM.The study groups consisted of 51 patients with type 2 DM, 28 patients with MS, and 26 pat...

The patient who was operated because of pituitary macroadenoma causing acromegaly disease had insufficient suppression respond of growth hormone to postoperative oral glucose tolerance test (OGTT). OCT LAR treatment had been started. On the 15.month of the therapy, the patient presented with failure of menstruation since four months, so pregnancy test was performed and pregnancy was diagnosed. The patient had used OCT LAR during the period without knowing that she was pregnant...

Diffuse sclerosing variant of papillary thyroid carcinoma is a rare variant. It is usually seen in children and young adults.The thyroid gland is diffusely involved. It is characterized by scattered microscopic tumor islands, diffuse fibrosis, calcification, abundant lymphocytic infiltration and psammom body when compared with conventional papillary thyroid carcinoma. Usually the lesion does not cause mass but rather a dominant nodule in one lobe is present in 50% of cases. Ly...

Vitamin D has immunomodulatory features and its deficiency is associated with the development of autoimmune diseases. The relation between vitamin D deficiency and autoimmune thyroiditis has not been investigated much. In the present study, our aim was to study the relation between vitamin D therapy and autoimmune thyroiditis.Fifty-four patients having newly diagnosed Hashimoto thyroiditis (HT) and vitamin D deficiency but requiring no thyroid hormone re...

Introduction: Hypoglycemia is the most common endocrinological problem in emergency departments.Objective: To explore the causes of hypoglycemia in patients who were admitted to the emergency department with symptoms resembling hypoglycemia.Design: In our study, 225 hypoglycemia cases were evaluated from January 2000 to May 2008.Results: Of 225 hypoglycemia cases, 158 (70.2%) receiving treatment for diabetes ...

Background: Plasma carnitine insufficiency has been caused muscle weakness. Carnitine levels and pulmonary functions were lower in patients with diabetes.Objective: To determine whether pulmonary functions are correlated with carnitine levels in patients with type 2 diabetes.Setting: Internal medicine outpatient clinic of a university hospital.Methods: Forty-nine patients with type 2 diabetes and 34 healthy c...